Ongoing subprojects

project_001


Evaluation and improvement of established diagnostic criteria for abnormal left ventricular filling

Principal investigator: Jonas Selmeryd, Ph.D. student, Dept. of Clinical Physiology Västerås, Sweden, Email: jonas.selmeryd@regionvastmanland.se.
Co-investigators: Pär Hedberg, associate professor, Dept. of Clinical Physiology Västerås, Sweden; Jerzy Leppert, professor, Centre for Clinical Research Uppsala university, Västerås, Sweden.

Heart failure with reduced ability to contract (HFrEF) is a well-characterized form of heart failure where consensus exists with regard to diagnostic criteria and treatment. Echocardiographic demonstration of reduced ejection fraction (EF) is a cornerstone of the diagnostic workup. An alternative form of heart failure is heart failure with preserved contractile function (HFpEF) – a common heart failure subtype with a prevalence that is increasing. With this kind of heart failure, a normal contractility is seen, but the filling of the heart is abnormal. As opposed to HFrEF, less is known about HFpEF and diagnostic criteria are still evolving. The current project aims at evaluating existing diagnostic criteria for abnormal left ventricular filling and see if improvements can be made.


Left atrial volumes and function in health and disease – reference values and prognostic impact

Principal investigator: Pär Hedberg, associate professor, Dept. of Clinical Physiology Västerås, Sweden, Email: par.o.hedberg@regionvastmanland.se.
Co-investigators: Jonas Selmeryd, Ph.D. student, Dept. of Clinical Physiology Västerås, Sweden; Jerzy Leppert, professor, Centre for Clinical Research Uppsala university, Västerås, Sweden.

Congestive heart failure is a growing public health problem. Impaired left ventricular pump function, usually as measured by a reduced left ventricular ejection fraction (LVEF), is a type of heart failure that is easily diagnosed using echocardiography. However, an increasingly common type of heart failure is characterized by a disturbed filling function of the left ventricle but with preserved LVEF. This type of heart failure (HFpEF) has a much more complex pathophysiology and its diagnostic criteria are still under development. Previous studies indicate that the left atrium plays a central role in HFpEF. The main aim of this project is to examine various aspects of left atrial characteristics in health and disease.


Prognostic value of screening multiple cardiovascular protein markers in patients with recent acute myocardial infarction and peripheral arterial disease

Principal investigator: Emma Skau, Ph.D. Student, Dept. of Clinical Physiology Västerås, Sweden, Email: emma.skau@regionvastmanland.se.
Co-investigators: Pär Hedberg, associate professor, Dept. of Clinical Physiology Västerås, Sweden; Jerzy Leppert, professor, Centre for Clinical Research Uppsala University, Västerås, Sweden

Cardiovascular disease is a major cause of morbidity and mortality in the western world. Clinical and biochemical risk factors/predictors now used in clinical practice have limited prognostic value. Inflammatory proteins (biomarkers), involved in atherosclerosis and in response to myocardial infarction, seem to have potential as valuable prognostic predictors. With a new technique for analysis of biomarkers (Proximity Extension Assay, PEA) developed by OLINK Proteomics in collaboration with Uppsala University, a large number of biomarkers from one single blood sample can simultaneously be analyzed. The objective is to identify the most important prognostic biomarkers in patients with cardiovascular disease, which could eventually become useful in routine medical care.