In the VaMIS cohort, consecutive patients admitted to the Department of Cardiology, Västmanland County Hospital, Västerås, Sweden, were included if they fulfilled the following criteria:
1. diagnosed with acute myocardial infarction
2. resident in the catchment area of the Västmanland County Hospital, Västerås, Sweden.
The acute myocardial infarction diagnose was based on the following criteria:
A troponin I level of ≥ 0,4 µg/L with a subsequent decline, combined with either:
a) ischemic symptoms,
b) ECG changes indicative of ischemia (ST elevation or depression),
c) development of Q waves on ECG, or
d) coronary artery intervention.
During the time between November 2005 and May 2011, there were 1459 patients fulfilling the inclusion criteria. Among these eligible patients, some were excluded because of language difficulties (n=57), dementia or confusion (n=81), other severe disease (n=62), logistical problems (n=106), reluctance to participate (n=50) och other reasons (n=95). Thus, 1008 (69,1 %) of the eligible patients constituted the final study population.
The participants underwent extensive examinations including:
- A questionnaire regarding previous and current medical problems, medication, tobacco and alcohol habits, physical activity, heredity, quality of life, type D personality etc.
- Measures of height, weight, waist, and hip. Blood pressures in arms and ankles
- Peak expiratory flow (PEF) and hand grip strength
- 12 lead resting ECG
- Ultrasonographic examinations of the heart (echocardiography) and arteries (carotid arteries, renal arteries, and abdominal aorta)
- Coronary angiography (in approximately 800 of the patients)
- Patients without previously known diabetes underwent an oral glucose tolerance test (measuring blood glucose in fasting state before and 120 minutes after intake of 75 g glucose)
- Blood analyses (including hemoglobin, leukocytes, creatinine, troponin I, HbA1c, total cholesterol and its fractions, triglycerides, apolipoproteins, CRP, cystatin C, NT-proBNP, insulin, proinsulin). In addition, blood samples are stored, aliquoted to microtubes, in freezers in the Ice hotel at the Uppsala Biobank, Uppsala, Sweden for future analyses.